安捷伦召开基因芯片技术应用巡回讲座-行业资讯

基因芯片技术已被广泛地应用于生命科学研究的各个领域。安捷伦科技有限公司将于2008年9月18日和19日分别在北京和上海举办基因芯片技术应用讲座。分别就miRNA 和CGH芯片技术在肿瘤等研究中的最新应用展开介绍。此次讲座邀请了:

Aberrant miRNA Expression in Human Breast Oncogenesis
by Alan Dombkowski, Ph.D.

Abstract:
Breast cancer is believed to develop in a multistep process with premalignant lesions preceding invasive carcinoma. While a growing body of recent work has demonstrated the role of microRNAs in cancer, little is known about the role of microRNAs in precancerous events that precede malignant transformation.In this work we used Agilent miRNA microarray platform to characterize miRNA expression changes associated with breast oncogenesis using a multistep cell line model that mimics the progression of breast cancer, from benign to premalignant to malignant transformation, and with corresponding mouse xenografts. Additionally, we used a bioinformatics tool developed in our laboratory, miR-AT, to identify biological processes and pathways associated with transcripts targeted by the miRNAs.

Integrative Analysis of Genomic Imbalances in Cancer

By Nallasivam Palanisamy, Ph.D.

Abstract:
Recurring non-random chromosome aberrations have been identified in hematological malignancies (leukemia and lymphoma) and soft tissue sarcomas. Among the various clonal aberrations, e.g. gene amplifications,deletions, inversions and duplicalions, chromosome lranslocations have been shown to have an important role in cancer development and they have been used as markers for diagnosis, prognosis and prediction of response to treatment . Current challenge is to understand the genetic complexity of solid tumors, because recurring chromosome abnormalities are difficult to ascertain in solid tumors by conventional karyotyping due to difficulties in chromosome preparation, poor morphology and high complexity of karyotype and clonal heterogeneity. High density oligonucleotide array-based comparative genomic hybridization (array CGH) is emerging as a powerful method for comprehensive analysis of unbalanced chromosome aberrations. In this presentation I will discuss the application of array CGH technology in solid tumor cancer research for the discovery of novel molecular markers.

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注册：本活动全程免费，席次有限，敬请立即报名！注册截止日期：2008年9月15日

日期：
北京：9/18（星期四）
北京东方花园饭店三层玉兰厅
北京东直门南大街6号

上海：9/19（星期五）
上海好望角大饭店五楼周仁厅
上海市肇嘉浜路500号

日程安排
8：45－9：00 签到
9：00－11：00 基因芯片技术讲座

安捷伦科技公司上海分公司
网址:http://www.agilent.com.cn

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